Divergent, C-C bond forming macrocyclizations using modular sulfonylhydrazone and derived substrates
Files
Accepted manuscript
Supporting documentation
Date
2021-12-03
Authors
Xu, Wenqing
Brown, Lauren E.
Porco, John A.
Version
Accepted manuscript
Supporting documentation
Supporting documentation
OA Version
Citation
W. Xu, L.E. Brown, J.A. Porco. 2021. "Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates." Journal of Organic Chemistry, Volume 86, Issue 23, pp.16485-16510. https://doi.org/10.1021/acs.joc.1c01848
Abstract
A divergent approach to C-C bond forming macrocycle construction is described. Modular sulfonylhydrazone and derived pyridotriazole substrates with three key building blocks have been constructed and cyclized to afford diverse macrocyclic frameworks. Broad substrate scope and functional group tolerance have been demonstrated. In addition, site-selective postfunctionalization allowed for further diversification of macrocyclic cores.