The asymmetric aldol reaction
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Asymmetric Aldol Reaction
Asymmetric Aldol Reaction
Date
2012-01-03
DOI
Authors
Mulcahy, Seann P.
Version
OA Version
Citation
Abstract
A convenient multi-week experiment that results in the formation of two new stereocenters starting from enantiopure norephedrine as the chiral auxiliary. This experiment uses a variety of purification techniques, including distillation, recrystallization, and column chromatography and is a useful extension of classroom topics. Students can be introduced to transition state modeling, COSY spectroscopy, Hammond postulate, and asymmetric induction.
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