Alterations in white matter of the brain after spinal cord injury
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Abstract
This study investigated potential alterations in brain white matter after spinal cord injury (SCI). Individuals with SCI underwent magnetic resonance diffusion tensor imaging (DTI) and alterations were assessed based on dynamic changes in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) parameters. Three contrast analyses compared FA and ADC values between person with SCI and healthy controls for the Boston cohort, the Denver cohort, and the grouped cohort. Persons with SCI were found to have lower FA and higher ADC values than health controls across all cohorts. These results are consistent with established correlations between DTI values and alteration of brain white matter in other chronic neurodegenerative conditions. This suggests that DTI is a useful tool for measuring white matter changes in the brain following SCI.
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Attribution-NonCommercial-NoDerivatives 4.0 International