Yang, ChenSharma, Vikrant2024-05-282024-05-282024https://hdl.handle.net/2144/48882Unforeseen off-target effects in clinical drug trials represent a growing expense in drug development. Biomimetic preclinical models that capture these off-target effects before human trials can maximally reduce these development costs, particularly for cardiotoxicity testing. As preclinical models, lab-grown organoids offer extremely high physiological accuracy yet exhibit high variance and complicated setup. To modulate cardiac organoid activities toward facilitating their development, this thesis developed induced-pluripotent stem cell cardiomyocyte (iPSC-CM) organoids and uses fiber optoacoustic emitters (FOEs) to photoacoustically stimulate cardiomyocyte organoids. As a platform for developing preclinical cardiac models, high-precision photoacoustic control offers a tunable, non-invasive system that offers insights into cell therapies and biomaterials to improve long-term patient outcomes.en-USAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/BioengineeringThesis/Dissertation2024-05-240009-0000-6451-8261