MED: General Surgery Papers
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Item Introducing Annals of Surgical Innovation and Research(BioMed Central, 2007-2-20) Matteotti, Ronald; Gagner, Michel; Becker, JamesItem Giant Organ Confined Prostatic Adenocarcinoma: A Case Report(BioMed Central, 2008-1-29) Brahmbhatt, Jamin V.; Liou, Louis S.INTRODUCTION Giant prostatic adenocarcinoma represents a rare and challenging treatment dilemma. CASE PRESENTATION We describe a case of an otherwise healthy 71-year-old African male who presented with a PSA of 5800 ng/ml and a prostate volume of over 1000cc. Unique aspects of this case include the size of the prostate, the apparent absence of distant metastases, and the safe usage of transabdominal biopsy of this mass. CONCLUSION We present this case report and review of literature to generate further discussion amongst readers as to management options for this difficult case.Item Strategy Escalation: An Emerging Paradigm for Safe Clinical Development of T Cell Gene Therapies(BioMed Central, 2010-6-10) Junghans, Richard PaulGene therapy techniques are being applied to modify T cells with chimeric antigen receptors (CARs) for therapeutic ends. The versatility of this platform has spawned multiple options for their application with new permutations in strategies continually being invented, a testimony to the creative energies of many investigators. The field is rapidly expanding with immense potential for impact against diverse cancers. But this rapid expansion, like the Big Bang, comes with a somewhat chaotic evolution of its therapeutic universe that can also be dangerous, as seen by recently publicized deaths. Time-honored methods for new drug testing embodied in Dose Escalation that were suitable for traditional inert agents are now inadequate for these novel "living drugs". In the following, I propose an approach to escalating risk for patient exposures with these new immuno-gene therapy agents, termed Strategy Escalation, that accounts for the molecular and biological features of the modified cells and the methods of their administration. This proposal is offered not as a prescriptive but as a discussion framework that investigators may wish to consider in configuring their intended clinical applications.Item Design, Conduct and Challenges of a Clinical Trial Utilizing Elastic Light Scattering Spectroscopy in the Thyroid(BioMed Central, 2010-10-29) Rosen, Jennifer; Suh, Hyunsuk; Lee, Stephanie; A'Amar, Ousama M.; Bigio, Irving