Graduate Research Symposium 2016
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Item Identification of miRNA differentially expressed in macrophages exposed to Porphyromonas gingivalis infection(2016-04-10) Al-Hashemi, Jacob; Huck, Olivier; Drizik, Eduard; Gower, Adam; Davideau, Jean-Luc; Tenenbaum, Henri; Amar, SalomonWe analyzed bacterial modulation of miRNAs in bone-marrow- derived macrophages (BMMs) induced by infection with either wild type Porphyromonas gingivalis (Pg) or mutant Pg (∆FimA), through a microarray analysis. TNF-α and IL-10 concentrations in Pg infected BMMs transfected with selected miRNAs were also assessed. The inhibition of mmu-miR-2137 increased the secretion of anti-inflammatory IL-10, while mmu-miR-155-5p decreased TNF-α. In vivo: injecting these miRNAs with Pg in mice reduced the size of the lesion significantly.Item The relationship between frontotemporal effective connectivity during picture naming, behavior, and preserved cortical tissue in chronic aphasia(Boston University, 2016) Meier, Erin L.; Kapse, Kushal J.; Kiran, Swathi